Wednesday, March 19, 2008

What is primary glomerular disease classification?

Primary glomerular disease is confined to the glomerular lesions or glomerular damage is mainly a group of kidney disease. Most primary glomerular disease idiopathic (of unknown etiology that is), a small portion of the bacterial infection or drug-induced. On the classification of primary glomerular diseases can be viewed from two aspects, that is, sub-clinical and pathological type.
1992 primary reference glomerular diseases clinical classification standards can be divided into:
(1) acute onset of acute glomerulonephritis, hematuria, proteinuria, edema and hypertension as the main performance, and there is a sexual azotemia a group of diseases. Was particularly prevalent in the streptococcal infection, other bacteria, viruses and parasites can also cause infection.
(2) rapidly progressive glomerulonephritis process and the onset of acute glomerulonephritis similar performance, but the rapid deterioration of renal function to, early in oliguric acute renal failure is characterized by a large number of pathological manifestations of crescentic Formation of a group of diseases.
(3) chronic glomerulonephritis for protracted illness, the slow progress of disease, will eventually develop into chronic renal failure for a group of glomerular diseases. Clinical to edema, hypertension, proteinuria, hematuria and renal damage as a basic performance, but because of disease and pathology of different types, their major performance differences, diverse.
(4) nephrotic syndrome mainly for the "three high and one low," that is, a high degree of swelling, proteinuria (≥ 3.5 g / day), hyperlipidemia and hypoalbuminemia (albumin ≤ 30 g / l ). As long as a large number of proteinuria and hypoproteinemia diagnosis can be established.
(5) occult glomerular diseases are asymptomatic proteinuria (urinary protein <1 g / day, mainly to albumin), and (or) isolated hematuria (continuous or intermittent microscopic hematuria, and occasionally the naked eye hematuria, the nature of the endogenous glomerular) for the clinical performance of a group of glomerular diseases. Patients with edema, hypertension and renal dysfunction.
According to the World Health Organization in 1982 on the primary glomerular disease pathological type standard, can be divided into:
① minor glomerular lesions; ② focal segmental lesions;
③ diffuse glomerulonephritis include: membranous nephropathy and proliferative glomerulonephritis (the latter can be divided into: mesangial proliferative glomerulonephritis, capillary proliferative glomerulonephritis, mesangial capillary nephritis, dense Sediments nephritis and crescentic glomerulonephritis) and sclerosing glomerulonephritis.
④ unclassified of glomerulonephritis.
Some can glomerular diseases under its immunofluorescence and (or) Immunohistochemistry results immune to pathological diagnosis, such as nephropathy IgM and IgA nephropathy.

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