Friday, August 15, 2008
Treatment of elderly people infected with liver cirrhosis
Concurrent with the treatment and attention to matters: Cirrhosis of older persons is the most common infections in spontaneous peritonitis, lung infections, gastro-intestinal infections, urinary tract infection. The most common pathogenic bacteria are gram-negative bacteria, and because of large-scale use of broad-spectrum antibiotics and immune dysfunction, anaerobic bacteria and fungal infections is increasing. Therefore, in elderly patients with cirrhosis infection should pay attention to the following questions: 1. Spontaneous peritonitis in elderly patients with liver cirrhosis in particular, ascites due to cirrhosis patients, abdominal infection is a common infection sites, so when patients with abdominal pain and the reasons could explain the elevated blood leukocytes, and the corresponding ascites in PMN (PMN )> 0.25 * 109 / L, should consider the possibility of spontaneous peritonitis. Should be selected in the ascites in a timely manner to reach adequate concentrations of broad-spectrum anti-Su. Penicillin and uncomfortable choice Tanzanian agents. If sultamicillin, or second, and third-generation cephalosporins, intravenous drug 10 to 14 for a course of treatment. 48 hours after repeated treatment of abdominal wear, check ascites, to estimate the effect of antibiotics. If the treatment effective, multi-shaped cells decreased more than 50 percent, bacterial culture negative, it is not necessary to replace antibiotics. For four days as invalid, or culture of drug use is not sensitive, required under the susceptibility testing or replacement of antibiotics. 2. More young people choose the right antibiotic repeated application of a variety of antibiotics, the elderly now have no application to the special anti-bacterial drug therapy is usually applied bactericidal drugs. Under the guidance of micro-organisms in the choice of drugs, more applications β-lactone Amine antibiotics, to avoid the application of security on the antibiotics. Oral antibiotics elderly and the absorption of young people without much different, the use of intramuscular injection of muscle tissue due to the elderly decreased, activity was relatively small and more young and middle-aged man-made low. Antibiotics into the blood, because the elderly to reduce serum albumin, the free serum concentration than the young people high. Principal places of antibiotics metabolism and excretion way to liver and kidney. The elderly should do everything possible to avoid the use of sugar-type drugs. To be used at small doses, to a short course of treatment, close observation of renal function. 3. To maintain the normal intestinal flora, Erchongganran prevent the permanent normal bacteria in the digestive tract at least 120 species. Bifidobacterium which is host to many important physiological functions, the reduction or disappearance of bacteria-causing bacteria and intestinal flora imbalance of intrusive. The elderly in the intestinal flora Bifidobacterium decreased significantly, and of Clostridium perfringens, Bacteroides and Enterobacter more. In the use of broad-spectrum antibiotics easily aroused dysbacteriosis, Erchongganran. Therefore, in large doses, prolonged use broad-spectrum antibiotics: 1) to pay attention to eating too much consumption of pork to make bogey, with more saturated fatty acids because the animal fat to the food structure of Bacillus and Clostridium reproduction role. Carbohydrates with crude for good. Cellulose with more food and vitamin B, can foster and promote anaerobic bacteria such as enterococci defecation. 2) the protection of anaerobic bacteria in the use of antibiotics for various infections, in addition to the eradication of blood or tissue anaerobic bacteria, the bacteria in the gut bacteria of oxygen must be protected, is the presence of anaerobic bacteria to resist colonization An important factor. 3) the rational use of antibiotics to avoid the use of antibiotics permanent injury.
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