Persistent pulmonary eosinophil infiltration

Overview persistent pulmonary eosinophil disease known as chronic eosinophilic pneumonia (chronic eosino philic pneumonia), by Carrington in 1969 first described, course and X-ray more often protracted, often more than one, the symptoms are more simple PIE to come. Etiology and generally cause simple pulmonary eosinophil infiltration of the similarities, some people think that it is Lu:fu sulfur syndrome type. Parasites by hookworm and roundworm caused most often see. Drugs to nitrofurantoin because styles. Ball also cause other bacteria spore disease, brucellosis and other diseases. Many patients Allergies, but their real incentive unknown. Pathological changes in interstitial and alveolar have intensive eosinophils and macrophage infiltration, accompanied by a small number of lymphocytes and plasma cells, the other, we can see that type II epithelial cells, alveolar protein leakage, fibroblast proliferation and collagen deposition interval. Eosinophils can produce heat to the original, leading to such patients often had fever symptoms. Diagnosis diagnosis often rely on the history and the typical X-ray findings. The disease with tuberculosis, Hodgkin's disease and other identification, if the diagnosis is in doubt, should strive for lung biopsy or bronchoalveolar lavage checks sometimes can be applied to adrenocorticotropic hormone for diagnostic treatment. Patients with clinical manifestations of male and female ratio of 1 : 2, ages 20 to 50 years old. Half of patients Allergies Symptoms range can only abnormal chest X-ray, but also to re-occurrence of respiratory failure. About one-course in August. Common symptoms of cough, fever, short breath, weight loss, night sweating, weakness, a small number of patients to have hemoptysis. More than half of patients can have a medical examination wheezing and could hear small wetlands rales. Typical performance of the X-ray diagnosis of common values, including three changes : ① with lobectomy or unrelated to the exudation of the shadows mainly in the lateral both lungs, was progress; ② adrenal corticosteroid use after exudative lesions rapid absorption; ③ With the clinical symptoms of repeated leakage also occurs repeatedly. PFT appearing restrictive ventilatory dysfunction associated with diffusion barriers and hypoxemia. Peripheral eosinophil proportion of 10% ~ 40% between ESR grew significantly faster up to 100 mm / h, Bronchoalveolar lavage fluid eosinophils ratio can be as high as 40% above normal and less than 1%, all of the above changes, After treatment can be dissipated. For less than 10% of patients can ease their own. Adrenocorticotropic hormone for the treatment of choice, usually prednisone 30-40mg / d, medication can occur a few hours after the temperature dropped and the general condition has improved, two days after a short breath and wheezing. cough and other symptoms have begun to improve, X-ray abnormalities in the regular medication two days after the improvement, in about two weeks to return to normal, all in the treatment of clinical manifestations in January after completely disappear. Taking into account the disease easy to relapse after withdrawal, the number of stand adrenocorticotropic hormone therapy to 6 ~ 12 months, patients need to have medication for several years. General maintenance treatment with prednisone 10 mg / d. If wheezing, and can increase with theophylline or category β2 - agonists.