Hoffmann's syndrome

Overview also known as adult A low myopathy. Pathology Disease (1) common thyroid in various sexual iodine treatment of hyperthyroidism, the thyroid may inflammation, surgical resection, iodine metabolism disorder, drugs, food and genetic factors. The main mechanism of thyroid hormone synthesis is inadequate. (2) As pituitary pituitary TSH secretion and release of inadequate thyroid occurred secondary hypothyroidism. Common causes of cancer, surgery, radiotherapy or postpartum necrosis. (3) Hypothalamic hypothalamic tumor, chronic inflammation and by the chronic radiation damage. TRH for lack of TSH secretion of thyroid hormone and has declined and caused three hypothyroidism. Clinical manifestations moves slow, sluggish appearance, dry skin, muscle rigidity and pain, muscle hypertrophy are distributed unevenly, to shoulder girdle muscles waist and thigh muscles mast more obvious, tongue and hands also mast. Deep reflection ankle reflex is particularly slow. Tap muscle after the place and cause muscle Confucius reaction (pseudo myotonia). EMG response was static electricity. Serum creatine phosphokinase (CPK) increased significantly. Thyroxine therapy effects. Differential diagnosis (1) endemic goiter (endemic goiter) this is the perturbation caused by the lack of iodine A Compensatory-gland swelling, the incidence was regional. Performance of goiter, exophthalmos, palpitation, more food, basal metabolic rate increased, and other symptoms of hyperthyroidism. Iodine treatment effects, when excessive iodine treatment or treatment for too long, can be perturbed by excessive iodine. Reflex cause TSH secretion, thus reducing synthetic thyroxine, occurred a low myopathy. Myopathy such as iodine therapy discontinued, the condition is expected to rapidly slow. (2) after thyroidectomy more because of simple goiter, thyroid cancer exact. Characterized shortly after emerging characteristic hypertrophic myasthenia gravis, the serum thyroxine levels were lower than normal. Along with the surgical thyroidectomy or injury, and the original incidence of thyroid caused by the degeneration and necrosis of the widely. (3) pituitary tumor (hypophysoma) performance of headache, visual impairment, Sella expand mass. Myopathy can occur in headache and visual impairment, can be the first symptom of myopathy. Apart from serum thyroxine levels low, there are other hormone imbalance. (4) A child with low myopathy (child hypothyroid myopathy) occurred in Children suffering from hypothyroidism, diffuse or limitations associated with muscle hypertrophy and myasthenia gravis and stunting. For the bad performance of a minor illness, painless spastic muscle rigidity and false. (5) chronic thyroid toxicity myopathy (chronic, involving myopathy) characterized by slow sexual weakness and muscle atrophy, also with pelvis, leg muscles significantly, involving the whole body muscle, mostly bilateral, accompanied obvious symptoms of hyperthyroidism, hyperthyroidism cured after MG gradually resume.