Giant cell tumor of bone

Overview of giant cell tumor of bone in China is the more common one of the primary bone tumors, the tumor growth active, of bone erosion devastating, if not in a timely and proper treatment, can cause serious disability and lead to amputation. a few of these cases can still transfer fatal. Circulating tumor rich, soft and brittle, like granulation tissue, easy bleeding, a plane of the fiber and hemorrhage. Cells consist of a round cell and spindle cell (mesenchymal cells), there is a larger gap within Gap signs of bleeding, and many multinucleated giant cells (~ 10 auditors 200), the thinning of cortical bone. sometimes through the cortex to expand the soft tissue biopsy of the tumor should include part. Currently, more inclined to pitch the stromal cells as the tumor's cells. Only clinical manifestations often secret anguish or irritation, intermittent attacks, local swelling can be. Because of misprision of progress, some tumors developed to a considerable size only to the treatment of multiple lesions on the two ends of long bones, Therefore joint activities can be restricted. The disease occurred in 80% of 20-year-old, rarely occurred in the past epiphyseal closure, only 3.5% below the age of 15. aged over 50 rarely see. See most of the 20-40-year-old. Benign giant cell tumor, more female than male, about 3 : 1; And the vicious, more male than female, and about 3:1. 75% of the tumors were located in the long bone of the extremities of 50% in the vicinity of the knee, the distal femur, proximal tibia and fibula. Distal radius and proximal humerus also often occur. Minorities found in the pelvis and spine. Occasionally were multiple reports. X-ray because the disease is the characteristic X-ray findings contribute to the early diagnosis, It is characterized by bone tissue focal osteolytic destruction. In the long bone epiphyses, and we can see a larger eccentric ray of light transmission; Lesions on the brink clear, which sees the rough or through the trabecular bone trabeculae not seen new bone formation and destruction on behalf of the epiphysis wall. Tumors can be extended to the articular cartilage and can even cause fractures, bone side of the right lower lobe of the cortex expanded and thinning obviously, outside in the bone cortex is not a general periosteal new bone formation, sometimes showing a soap bubble or cystic-like changes. Some huge, expansive tumor may relate metaphysis and epiphysis can occupy all of a thin layer of hardened borders, by expanding the inner cortical shrinkage or a small amount of peripheral reaction caused new bone formation. Also see the formation of a typical manifestation periosteal reaction as 1.30. Since tumor growth, was peeling from the periosteum. If the cortical surface of the skin tumor rupture, periosteal new bone has suggested a number of malignant transformation possible. A diagnosis. Common in young adults aged 20-40. 2. Occur in the extremities long bone metaphysis, particularly common in the distal femur and proximal tibia. 3. Local pain and tenderness. Pain and early intermittent secret anguish. Pain severity and speed of the tumor growth into sustained pain expressed for malignant transformation possible. 4.X ray Features. 5. Pathological examination can be diagnosed. Treatment based on the natural history of disease. Hutter such that a man with about 30% recurrence in two years, 50% in five years recurrence. All patients relapse occurred in 90% within five years. So after five years of local recurrence should be considered malignant transformation possible. They reported via a surgery and cured only 1 / 3 cases, the two also cured for 1 / 3 cases, the remaining 1 / 3 by 3 ~ 5 times before being radical surgery. So if I want a cure is surgery, we must take radical surgery, which is the total removal of the tumor. appropriate organizations, including the large normal surgery. Curettage and bone Thompon reports, the first one after the recurrence rate of 29.6% to the 5-year recurrence rate rose to 54.1%, about 10% of giant cell tumor of bone malignant transformation. This similarly shows that the majority of the giant cell tumor of bone graft and curettage term treatment is not appropriate, on the trunk of the bone by giant cell tumor of bone after curettage and prognosis than those limbs to intervene. By curettage and relapse cases, a person may malignant transformation of the festival should consider resection was chosen, Segmental resection while feasible arthrodesis, semi-articular graft prosthesis or angioplasty. Of primary malignant giant cell tumor or malignant transformation of sarcoma were required amputation, a wide range of tumor lesions or invasive soft tissue segment of reconstruction after resection difficult limb function or not achieve radical also demanded to be considered amputation. Radiation exposure after sarcoma more opportunities for change, only in certain parts of the human body not only at the time of surgery prudent choice. Auxiliary X-ray inspection performance : epiphysis limitations of the Department of cystic change, the general osteolytic destruction. may have "bubble" like change, which is generally expanding cartilage constraints. Not broken into the joint, a rare periosteal reaction, tumor scope clear at the onset of the disease within the lateral epiphysis. development that could account for the full-bone, bone thinning of cortical expansion, some of them may be to break into the soft tissue. X-ray can show that its general characteristics, it is still insufficient diagnosed.