Aronld-Pick's Syndrome

Lobes of the brain known as outlined sclerosis; Lobe atrophy; Alzheimer's disease; Aphasia-discriminating loss-not campaign syndrome; Pick (A)'s syndrome. Cause pathogenesis of unknown etiology may have a family-type degeneration. Bilateral pathological changes of brain atrophy, largely confined to the temporal lobe and frontal, parietal less affected. Lesions shedding regional nerve cells, stromal osteoporosis, the brittle within a slurry ARGYROPHIL body, Pick inclusion. Visibility shrinking zone senile plaques and neurofibrillary tangles of fibers. Clinical manifestations of the disease more than 40 ~ 60-year-old disease, the higher the incidence of women, slow dementia, in recent memory gradually lost. Inarticulate, pronunciation vague, disorganized speech. Personality and behavior changes, thinking obvious obstacles, more sleep. See the light hemiplegia, tremors, convulsions. Hyperreflexia or weakened. EEG showed diffuse dysrhythmia, high amplitude slow activities. Brain CT scan showed brain atrophy leaves symmetry to the amount of temporal lobe Obviously, sometimes in the white matter demyelination. Differential diagnosis (1) simple senile dementia (simple senile dementia) for more than seven 0 after the age of onset, memory disorders often start with (first thing for nearly forgotten, after remote memory loss), and hamartoma fictitious disease, Recognizing errors. Visibility language barrier and not the proper use of fertilizer vocabulary, but also a structure of apraxia, but no other signs of a language barrier. In addition to the limb muscle tension hyperthyroidism, and mild or no fixed-grip reflex, neurological examination was little positive signs. (2) Alzheimer's type senile dementia (Alzheimer-senile demen Acronyms) in the above simple senile dementia symptoms above, appeared increasingly obvious aphasia - apraxia - agnosia syndrome; often associated with prefrontal symptoms, If the lips are reflected (in some basic 12/85 used as savvy aroused); significant resistance muscle tension hyperthyroidism, stereotyped movements, eye movement disorders; there will be Balint-like syndrome and speech repeat. Epilepsy can also occur twitch muscle Fine Chocolate and sexual twitch. (3) Pick's disease (Pick's disease) incidence of the disease retardation, some mental trauma are often perceived to be the pathogenesis of incentives. The disease clinically with Alzheimer disease almost impossible to identify, to the limitations of cerebral atrophy and and the extent of atrophy on both sides often asymmetrical, in the frontal lobe atrophy most see limitations. See the enlarged ventricle. Under a microscope without senile plaques and neurofibrillary tangles and fiber Pick inclusion.